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KMID : 0361020240670030152
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Korean Journal of Otolaryngology - Head and Neck Surgery
2024 Volume.67 No. 3 p.152 ~ p.158
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The Correlation of Tissue’s Endotype Biomarkers and Dominant Inflammation Cell in Chronic Rhinosinusitis
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Iriana Maharani
Monica Intan
Dyah Indrasworo
Kenty Wantri Anita
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Abstract
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Background and Objectives This study analyzes the relationship between endotype bio-markers and the type of tissue inflammation in chronic rhinosinusitis (CRS) in order to obtaina more accurate division of disease groups and appropriate therapy.
Subjects and Method We carried out a cross-sectional study involving 33 samples of CRSpatients. We conducted enzyme-linked immunosorbent assay to examine endotype biomark-ers and histopathology methods to examine tissue inflammation.
Results Statistical analysis with an independent t-test showed significant differences withrespect to eosinophil cationic protein (ECP) between the eosinophilic and neutrophilic groups( p<0.05), whereas there were no significant differences between the two groups ( p>0.05) withrespect to Charcot-Leyden crystal (CLC), interleukin-5 (IL-5), interferon gamma (IFN-γ), in-terleukin-17A (IL-17A), and oncostatin M (OSM). The Spearman test showed also showed thatECP, CLC, IL-5, IL-17A, IFN-γ and OSM had no significant correlation with the two groups( p>0.05). The receiver operating characteristics analysis showed the optimal cut-off value ofECP of 342.22 pg/mL with sensitivity and specificity of 72.7% for determining the inflamma-tion type (area under cover=0.78, p=0.009).
Conclusion The higher level of ECP was more likely to be found in the eosinophilic tissueinflammation. Consequently, we propose using ECP as the main biomarker to identify the CRStype 2. Further research with a larger sample size is required for cut-off points of ECP in orderto determine the endotype of CRS.
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KEYWORD
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Nasal mucosa, Paranasal sinus disease, Sinusitis
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